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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Pla2g10 - phospholipase A2, group X
Alias:
PLA2GX
sPLA2-X
GX sPLA2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码磷脂酶A2家族成员,该家族成员能够水解甘油磷脂生成游离脂肪酸和溶血磷脂。编码的蛋白质经过蛋白水解加工,生成一种依赖钙离子的酶,该酶在从膜磷脂中释放花生四烯酸的过程中发挥关键作用,从而产生各种炎症脂质介质,如前列腺素。在心肌缺血/再灌注反应中,缺乏编码蛋白质的小鼠心肌梗死面积减少,部分原因是通过抑制中性粒细胞细胞毒活性的抑制。可变剪接导致多个转录变异体,编码不同的异构体。所有这些异构体可能经历相似的加工过程,以生成成熟蛋白质。[由RefSeq,2015年7月提供]
Related ID:
NCBI:26565
ENSEMBL:ENSMUSG00000022683
UNIPROT:Q9QXX3
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
26565
3
4
15943 bp
17.00
8
19
Pla2g10 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Type
Name
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