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中文人类
LATS2 - Large Tumor Suppressor Kinase 2
Alias:
KPM
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这个基因编码一个属于LATS肿瘤抑制家族的丝氨酸/苏氨酸蛋白激酶。在细胞周期中，该蛋白定位在中心体上，并在早期和晚期的有丝分裂阶段。它与其他中心体蛋白aurora-A和ajuba相互作用，并在有丝分裂开始时积累γ-微管蛋白和纺锤体形成中发挥作用。它还可以与p53的负调控子相互作用，并且可能与p53一起参与对细胞骨架损伤作出反应的正反馈循环。此外，它还可以作为雄激素响应基因表达的共同抑制子。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
LATS2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
