Map3k1 - mitogen-activated protein kinase kinase kinase 1

Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including JNK cascade; eyelid development in camera-type eye; and positive regulation of actin filament polymerization. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]