Map2k6 - mitogen-activated protein kinase kinase 6

Enables MAP kinase kinase activity; phosphatase activator activity; and protein serine/threonine kinase activator activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAP kinase activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]