人类

FBXO22 - F-box Protein 22

Alias:
FBX22
FISTC1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码F-box蛋白家族的一员,其特征是一个大约40个氨基酸的基序,即F-box。F-box蛋白构成了泛蛋白连接酶复合物(称为SCFs,SKP1-cullin-F-box)的四个亚基之一,该复合物在磷酸化依赖的泛蛋白酶作用中发挥作用。F-box蛋白分为三类:包含WD-40结构的Fbws,包含富亮氨酸重复序列的Fbls,以及包含不同蛋白质-蛋白质相互作用模块或无明显识别基序的Fbxs。这个基因编码的蛋白质属于Fbxs类,并被肿瘤蛋白p53作为转录靶标,被认为参与响应p53诱导的特定蛋白质的降解。可变剪接导致多个转录变异体。[RefSeq,2010年12月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3
7
38634 bp
44.51
13
--
5
11

FBXO22 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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