Dclre1c - DNA cross-link repair 1C

Predicted to enable 5'-3' exodeoxyribonuclease activity; damaged DNA binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and protection from non-homologous end joining at telomere. Predicted to act upstream of or within B cell differentiation; DNA metabolic process; and response to ionizing radiation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of nonhomologous end joining complex. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C). [provided by Alliance of Genome Resources, Apr 2022]