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中文人类
SPDEF - SAM Pointed Domain Containing ETS Transcription Factor
Alias:
PDEF
bA375E1.3
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这个基因编码的蛋白质属于ETS家族转录因子。它在前列腺上皮细胞中高度表达，并作为前列腺特异性抗原（PSA）启动子的非激素依赖性转激活子发挥作用。与相应的正常组织相比，这个蛋白质在脑、乳腺、肺和卵巢肿瘤中的表达也较高，与其他癌症相关分子相比，它表现出更好的肿瘤相关性，使其成为开发特异性癌症治疗更合适的靶点。已经发现这个基因的替代剪接转录变异体编码不同的异构体。[RefSeq, Nov 2011提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SPDEF Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
