Enables argininosuccinate synthase activity and toxic substance binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and cellular response to organonitrogen compound. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Biomarker of uveitis. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]