Abcc8 - ATP binding cassette subfamily C member 8

Predicted to enable ATPase-coupled cation transmembrane transporter activity; potassium channel activity; and transmembrane transporter binding activity. Involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in sarcolemma and synaptic vesicle membrane. Part of inward rectifying potassium channel. Colocalizes with mitochondrion. Used to study brain edema; cardiac arrest; hypoglycemia; and middle cerebral artery infarction. Biomarker of Parkinsonism; sciatic neuropathy; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]