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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Selenow - selenoprotein W
Alias:
SelW
Sepw1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个含有硒半胱氨酸(Sec)残基的硒蛋白,这个Sec残基是由UGA密码子编码的,正常情况下,这个密码子表示翻译终止。硒蛋白的mRNA的3'UTR含有一个保守的茎环结构,这个结构是SECIS元件,对于识别UGA作为Sec密码子而不是作为终止信号是必要的。这个蛋白在骨骼肌和大脑中高度表达。它属于SelWTH家族,这个家族具有一个类似硫氧还蛋白的折叠结构和一个保守的CxxU(C是半胱氨酸,U是Sec)基序,这表明这个基因具有一个氧化还原功能。研究表明,这个硒蛋白参与肌肉生长和分化,以及在神经元发育过程中保护神经元免受氧化应激的影响。在这个位置的假基因已经在染色体10上被鉴定出来。[由RefSeq,2017年8月提供]
Related ID:
NCBI:25545
ENSEMBL:ENSRNOG00000067799
UNIPROT:P63301
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
25545
1
6
5074 bp
9.69
8
5
Selenow Genetics information (-)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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