Psap - prosaposin

Predicted to enable several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity. Predicted to be involved in several processes, including ganglioside GM1 transport to membrane; positive regulation of beta-galactosidase activity; and prostate gland development. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within several processes, including animal organ development; glycosylceramide metabolic process; and protein transport. Predicted to be located in aggresome; extracellular region; and late endosome. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin). [provided by Alliance of Genome Resources, Apr 2022]