Cacna1a - calcium voltage-gated channel subunit alpha1 A

Enables calmodulin binding activity and high voltage-gated calcium channel activity. Involved in several processes, including calcium ion import; regulation of voltage-gated calcium channel activity; and sensory perception of pain. Located in perikaryon and plasma membrane. Part of voltage-gated calcium channel complex. Is integral component of presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]