Enables serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Located in dendrite and perikaryon. Colocalizes with secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]