Hsd11b2 - hydroxysteroid 11-beta dehydrogenase 2

Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to food. Located in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]