Itgam - integrin subunit alpha M

Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Predicted to be involved in several processes, including endocytosis; positive regulation of myeloid leukocyte mediated immunity; and positive regulation of neuron death. Predicted to act upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular space; and plasma membrane raft. Predicted to be integral component of membrane. Predicted to be part of integrin alphaM-beta2 complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]