Lox - lysyl oxidase

Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including extracellular matrix organization; response to steroid hormone; and wound healing. Acts upstream of or within several processes, including cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix and nucleus. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase). [provided by Alliance of Genome Resources, Apr 2022]