Tph1 - tryptophan hydroxylase 1

Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Located in neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]