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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Tp53 - tumor protein p53
Alias:
p53
Trp53
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码肿瘤蛋白p53,它响应多种细胞压力来调节诱导细胞周期停滞、凋亡、衰老、DNA修复或代谢变化的目标基因。p53蛋白在正常细胞中表达水平较低,在各种转化细胞系中表达水平较高,被认为有助于转化和恶性化。p53是一种含有转录激活、DNA结合和寡聚化结构域的DNA结合蛋白。据推测,它结合到一个p53结合位点,并激活下游抑制生长和/或侵袭的基因表达,从而起到肿瘤抑制因子的作用。已经发现这个基因的替代剪接转录变异体,但是变异体的生物学有效性尚未确定。在这个基因的染色体9和18上发现了p53假基因。[由RefSeq,2008年7月提供]
Related ID:
NCBI:24842
ENSEMBL:ENSRNOG00000010756
UNIPROT:P10361
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
24842
5
11
11456 bp
43.45
124
6
Tp53 Genetics information (+)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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