Enables several functions, including protein C-terminus binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; exocytosis; and regulation of delayed rectifier potassium channel activity. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]