Scnn1b - sodium channel epithelial 1 subunit beta

Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in several processes, including response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]