Predicted to enable serine-type endopeptidase activity. Involved in response to caffeine; response to nicotine; and response to nutrient. Located in extracellular space. Biomarker of cystic fibrosis; pancreatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS1 (serine protease 1) and PRSS3 (serine protease 3). [provided by Alliance of Genome Resources, Apr 2022]