Muc1 - mucin 1, cell surface associated

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to retinoic acid; female pregnancy; and response to hypoxia. Located in apical plasma membrane and cytoplasm. Used to study allergic rhinitis. Biomarker of allergic rhinitis; cholangiocarcinoma; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]