Kras - KRAS proto-oncogene, GTPase

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; and response to corticosteroid. Located in membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]