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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Grin2a - glutamate ionotropic receptor NMDA type subunit 2A
Alias:
NR2A
GluN2A
NMDAR2A
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
具有多种功能,包括酶结合活性;谷氨酸结合活性;以及配体门控离子通道活性。参与阳离子通道活性和细胞外谷氨酸门控离子通道活性。涉及几个过程,包括细胞对金属离子的反应;中枢神经系统发育;以及化学突触传递的调节。位于几个细胞成分中,包括树突棘;突触后密度;以及突触膜。是质膜的整合成分。是NMDA选择性谷氨酸受体复合物的组成部分。在谷氨酸能突触和平行纤维到蒲肯野细胞突触中是活跃的。是突前膜的整合成分。用于研究高同型半胱氨酸血症。认知障碍;胎盘功能不足;和癫痫状态的标志物。这个基因的人类同源物与亨廷顿病;双相障碍;和精神分裂症有关。与人类GRIN2A(谷氨酸离子型受体NMDA型亚单位2A)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:24409
ENSEMBL:ENSRNOG00000033942
UNIPROT:Q00959
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
24409
1
16
423580 bp
165.47
13
27
Grin2a Genetics information (+)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
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