Drd1 - dopamine receptor D1

Enables several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and response to alkaloid. Located in several cellular components, including caveola; dendrite; and neuronal cell body. Is integral component of membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinson's disease; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; hyperglycemia; neurodegenerative disease (multiple); tracheal stenosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Apr 2022]