Enables several functions, including ATP binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in several processes, including cation transport; cellular response to mechanical stimulus; and negative regulation of calcium:sodium antiporter activity. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]