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中文人类
ALOX5 - Arachidonate 5-lipoxygenase
Alias:
5-LO
5LPG
LOG5
5-LOX
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这个基因编码脂氧合酶基因家族的成员，并在花生四烯酸合成白三烯中起到双重作用。编码的蛋白质在骨髓衍生细胞中特异性表达，催化花生四烯酸向5(S)-羟过氧化物-6-反式-8,11,14-顺式-二十碳四烯酸转化，进一步转化为烯丙基环氧化物5(S)-反式-7,9-反式-11,14-顺式-二十碳三烯酸(白三烯A4)。白三烯是许多炎症和过敏症状的重要介质。这个基因启动子区域的突变导致对用于治疗哮喘的抗白三烯药物的反应减弱，也可能与动脉粥样硬化和几种癌症有关。这个基因的不同剪接转录变异体已经发现。[RefSeq，2012年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ALOX5 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
