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中文小鼠
Bace1 - beta-site APP cleaving enzyme 1
Alias:
ASP2
Bace
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这个基因编码肽酶A1家族的天冬氨酸蛋白酶成员。可变剪接产生多种转录子变异体，其中至少一种编码前原蛋白，该前原蛋白在蛋白水解过程中被加工成成熟的蛋白酶。这种跨膜蛋白酶催化了从淀粉样前体蛋白形成淀粉样β肽的第一步。淀粉样β肽是淀粉样β斑块的主要组成成分，这些斑块在人类阿尔茨海默病患者的大脑中积累。这个基因的纯合子敲除小鼠表现出广泛的神经系统缺陷、生长迟缓、代谢异常和新生儿死亡率增加。[RefSeq, Nov 2015提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Bace1 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
