Apc2 - APC regulator of WNT signaling pathway 2

Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytoskeleton; lamellipodium membrane; and midbody. Predicted to be part of beta-catenin destruction complex; catenin complex; and filamentous actin. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including appendicular skeleton; axial skeleton; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Apr 2022]