Amfr - autocrine motility factor receptor

Predicted to enable several functions, including BAT3 complex binding activity; chaperone binding activity; and ubiquitin-specific protease binding activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Predicted to be integral component of endoplasmic reticulum membrane and integral component of plasma membrane. Predicted to be part of Derlin-1 retrotranslocation complex and ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Apr 2022]