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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
FLRT2 - Fibronectin Leucine Rich Transmembrane Protein 2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码纤维连接蛋白富含亮氨酸的跨膜(FLRT)家族的一员,该家族调节早期胚胎血管和神经发育。编码的I型跨膜蛋白具有一个细胞外区域,该区域由N-端富含亮氨酸的重复结构域和3型纤维连接蛋白结构域组成,后面是一个跨膜结构域和一个短的C-端细胞质尾结构域。它既作为同亲性细胞粘附分子又作为异亲性化学排斥剂发挥作用,通过与Uncoordinated-5受体家族的成员相互作用。蛋白水解去除细胞外区域控制发育中神经元的迁移。可选剪接产生多个转录变异体。[由RefSeq,2016年9月提供]
Related ID:
NCBI:23768
ENSEMBL:ENSG00000185070
HGNC:3761
UNIPROT:O43155
OMIM:604807
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
23768
6
2
124285 bp
74.05
28
--
9
6
FLRT2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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