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中文人类
RASD2 - RASD Family Member 2
Alias:
Rhes
TEM2
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这个基因属于Ras超家族的小GTP酶，并在纹状体中富集。编码的蛋白质作为E3连接酶，用于附着小型泛蛋白样修饰物（SUMO）。该蛋白质还与亨廷顿病（HD）中突变的高亨廷蛋白（mHtt）结合。这个蛋白质通过SUMO化修饰mHTT，可能导致纹状体的退化。该蛋白质作为雷帕霉素1（mTOR1）的激活剂，进而参与髓鞘形成、轴突生长和再生。在HD患者中，这个基因表达的mRNA水平降低。[RefSeq，2016年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
RASD2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
