Lingo1 - leucine rich repeat and Ig domain containing 1

Enables epidermal growth factor receptor binding activity. Acts upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; central nervous system; gut; sensory organ; and somite. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]