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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Ces2c - carboxylesterase 2C
Alias:
Ces2
CES 2
ACH M1
ces2A3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码羧酸酯酶大家族的一员。这个家族的成员负责水解或转移各种外源性物质,如可卡因和海洛因,以及具有酯、硫酯或酰胺键的内源性底物。它们可能参与脂肪酸和胆固醇酯的代谢,并在血脑屏障系统中发挥作用。这个基因编码的蛋白质是主要的肠道酶,在肠道药物清除中发挥作用。这个基因的转录受到几种因素的调节,包括HNF-4alpha(肝细胞核因子-4alpha)、Sp1(特异性蛋白1)、Sp3和USF1(上游刺激因子1)。这个基因的表达和活性与年龄相关,但不受生长激素水平的影响。这个基因与几个家族成员聚集在一起,包括几个假基因和Ces5,位于染色体8上。[RefSeq提供,2010年6月]
Related ID:
NCBI:234671
ENSEMBL:ENSMUSG00000061825
UNIPROT:Q91WG0
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
234671
1
12
7416 bp
62.47
2
4
Ces2c Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
Length(nt)
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* This data comes from NCBI.
Gene Expression
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Name
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