Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within endocytosis. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]