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中文人类
PHLPP1 - PH Domain And Leucine Rich Repeat Protein Phosphatase 1
Alias:
SCOP
PHLPP
PPM3A
PLEKHE1
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这个基因编码丝氨酸/苏氨酸磷酸酶家族的一员。编码的蛋白质通过去磷酸化并失活丝氨酸/苏氨酸激酶Akt来促进凋亡，并在多种类型的癌症中作为肿瘤抑制因子发挥作用。这个基因的过度表达也可能通过干扰Akt介导的胰岛素信号传导在肥胖和2型糖尿病中发挥作用。[由RefSeq, 2011年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PHLPP1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
