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中文人类
FLT3 - Fms Related Receptor Tyrosine Kinase 3
Alias:
FLK2
STK1
CD135
FLK-2
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这个基因编码一个III类受体酪氨酸激酶，可调节造血作用。这个受体通过结合fms相关酪氨酸激酶3配体来激活细胞外结构域，从而在质膜中诱导同源二聚体的形成，导致受体的自身磷酸化。活化的受体激酶随后在涉及骨髓中造血细胞凋亡、增殖和分化的途径中磷酸化并激活多个细胞质效应子分子。导致这个受体组成性激活的突变会导致急性粒细胞白血病和急性淋巴细胞性白血病。[RefSeq，2015年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
FLT3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
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CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
