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Tardbp - TAR DNA binding protein

Alias:
Tdp43
TDP-43
1190002A23Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种蛋白质,能够与RNA聚合酶II结合,并参与蛋白质在细胞核内的输入调控、生物钟调控以及蛋白质稳定性的调控。该基因位于细胞核内,并在多个组织中表达,包括鳃弓、中枢神经系统、早期胎囊、生殖泌尿系统和心脏。该基因用于研究与TDP43包涵体相关的Grn相关额颞叶变性、肌萎缩侧索硬化症10型和额颞部痴呆。人类该基因的同源基因与帕金森病、肌萎缩侧索硬化症、肌萎缩侧索硬化症10型和运动神经元疾病有关。该基因与人类TARDBP(TAR DNA结合蛋白)具有同源性。[由基因组资源联盟,2022年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
6
6
14834 bp
44.55
32
18

Tardbp Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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