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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Tardbp - TAR DNA binding protein
Alias:
Tdp43
TDP-43
1190002A23Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种蛋白质,能够与RNA聚合酶II结合,并参与蛋白质在细胞核内的输入调控、生物钟调控以及蛋白质稳定性的调控。该基因位于细胞核内,并在多个组织中表达,包括鳃弓、中枢神经系统、早期胎囊、生殖泌尿系统和心脏。该基因用于研究与TDP43包涵体相关的Grn相关额颞叶变性、肌萎缩侧索硬化症10型和额颞部痴呆。人类该基因的同源基因与帕金森病、肌萎缩侧索硬化症、肌萎缩侧索硬化症10型和运动神经元疾病有关。该基因与人类TARDBP(TAR DNA结合蛋白)具有同源性。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:230908
ENSEMBL:ENSMUSG00000041459
UNIPROT:Q921F2
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
230908
6
6
14834 bp
44.55
32
18
Tardbp Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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