Rigi - RNA sensor RIG-I

Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Involved in innate immune response; positive regulation of cytokine production; and response to virus. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in several cellular components, including actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; olfactory epithelium; ovary; and renal calyx. Orthologous to human DDX58 (DExD/H-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]