人类

DKK1 - Dickkopf WNT Signaling Pathway Inhibitor 1

Alias:
SK
DKK-1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个Dickkopf家族蛋白成员。这个家族的成员是分泌型蛋白质,其特征是具有两个介导蛋白质之间相互作用的富含半胱氨酸的结构域。编码的蛋白质与LRP6共受体结合,并抑制β-连环蛋白依赖的Wnt信号传导。这个基因在胚胎发育中发挥作用,可能在成人骨形成中也很重要。这个基因的过度表达在许多人类癌症中观察到,这个蛋白质可能促进癌细胞系的增殖、侵袭和生长。[由RefSeq,2017年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
4
3377 bp
28.67
15
2
14
15

DKK1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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