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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
DKK1 - Dickkopf WNT Signaling Pathway Inhibitor 1
Alias:
SK
DKK-1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个Dickkopf家族蛋白成员。这个家族的成员是分泌型蛋白质,其特征是具有两个介导蛋白质之间相互作用的富含半胱氨酸的结构域。编码的蛋白质与LRP6共受体结合,并抑制β-连环蛋白依赖的Wnt信号传导。这个基因在胚胎发育中发挥作用,可能在成人骨形成中也很重要。这个基因的过度表达在许多人类癌症中观察到,这个蛋白质可能促进癌细胞系的增殖、侵袭和生长。[由RefSeq,2017年9月提供]
Related ID:
NCBI:22943
ENSEMBL:ENSG00000107984
HGNC:2891
UNIPROT:O94907
OMIM:605189
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
22943
1
4
3377 bp
28.67
15
2
14
15
DKK1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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