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中文小鼠
Dclre1c - DNA cross-link repair 1C
Alias:
Art
Snm1l
9930121L06Rik
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这个基因编码SNM1家族核酸酶成员，参与V(D)J重组和DNA修复。这个蛋白具有单链特异性的5'-3'外切核酸酶活性；它还在5'和3'突出端和发卡结构上表现出核酸内切酶活性。该蛋白还在响应DNA损伤的细胞周期调节中发挥作用。这个基因的纯合敲除小鼠表现出严重的联合免疫缺陷，对电离辐射敏感。人类中这个基因的突变可能导致Athabascan型严重联合免疫缺陷（SCIDA）和Omenn综合征。可变剪接导致编码不同异构体的多种转录变异体。[由RefSeq，2014年11月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Dclre1c Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
