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中文人类
FHIT - Fragile Histidine Triad Diadenosine Triphosphatase
Alias:
FRA3B
AP3Aase
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这个基因编码的蛋白质是一种P1-P3-二(5'-腺苷酰)三磷酸酶，参与嘌呤代谢。这个基因包含了染色体3上的常见脆性位点FRA3B，在那里致癌物质诱导的损伤可能导致易位和异常转录。实际上，从这个基因中发现的异常转录物已经在大约一半的食管、胃和结肠癌中被发现。编码的蛋白质也是一种肿瘤抑制因子，因为其活性的丧失导致复制压力和DNA损伤。[RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
FHIT Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
