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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
FGB - Fibrinogen Beta Chain
Alias:
HEL-S-78p
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是纤维蛋白原的β链成分,它是一种血液内的糖蛋白,由三对不同的多肽链组成。在血管损伤后,纤维蛋白原被凝血酶切割形成纤维蛋白,它是血液血栓中最丰富的成分。此外,纤维蛋白原和纤维蛋白的各种切割产物调节细胞粘附和扩散,显示血管收缩和化学趋化活性,并对几种细胞类型具有促有丝分裂作用。纤维蛋白原在止血和抗菌宿主防御中起着关键作用。这个基因的突变导致几种疾病,包括纤维蛋白原血症、纤维蛋白原异常血症、低纤维蛋白原血症和血栓倾向。[RefSeq,2020年8月提供]
Related ID:
NCBI:2244
ENSEMBL:ENSG00000171564
HGNC:3662
UNIPROT:P02675
OMIM:134830
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
2244
9
8
9828 bp
55.93
165
5
4
33
FGB Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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