小鼠

Vip - vasoactive intestinal polypeptide

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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这种基因编码一种具有强大支气管扩张剂、免疫调节和抗炎特性的胰高血糖素/分泌素超家族的神经肽。编码的蛋白质被蛋白水解加工,生成两种结构相似的神经营肽-血管活性肠肽(VIP)和组氨酸-异亮氨酸肽(PHI)。在消化道中,VIP刺激肠平滑肌的松弛、水和电解质的分泌、胰岛素和胰高血糖素的释放以及胃酸分泌的抑制。在心血管系统中,VIP导致冠状血管扩张并刺激心脏的收缩性。缺乏VIP的小鼠表现出气道高反应性和气道炎症。缺乏VIP的雄性小鼠表现出中度肺动脉高压,导致死亡率增加。可变剪接产生多种编码不同异型体的转录变异体。[由RefSeq,2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
8
7
8487 bp
19.05
9
6

Vip Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
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Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
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