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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Vip - vasoactive intestinal polypeptide
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这种基因编码一种具有强大支气管扩张剂、免疫调节和抗炎特性的胰高血糖素/分泌素超家族的神经肽。编码的蛋白质被蛋白水解加工,生成两种结构相似的神经营肽-血管活性肠肽(VIP)和组氨酸-异亮氨酸肽(PHI)。在消化道中,VIP刺激肠平滑肌的松弛、水和电解质的分泌、胰岛素和胰高血糖素的释放以及胃酸分泌的抑制。在心血管系统中,VIP导致冠状血管扩张并刺激心脏的收缩性。缺乏VIP的小鼠表现出气道高反应性和气道炎症。缺乏VIP的雄性小鼠表现出中度肺动脉高压,导致死亡率增加。可变剪接产生多种编码不同异型体的转录变异体。[由RefSeq,2015年9月提供]
Related ID:
NCBI:22353
ENSEMBL:ENSMUSG00000019772
UNIPROT:P32648
Basic Information
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Transcripts
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Length
MW (kDa)
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22353
8
7
8487 bp
19.05
9
6
Vip Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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