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Tyms - thymidylate synthase

Alias:
Ts
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种酶,该酶使用5,10-亚甲基四氢叶酸作为辅因子,催化脱氧尿苷酸甲基化为脱氧胸苷酸。这个功能维持了胸苷-5'-单磷酸盐的浓度,这对于DNA复制和修复至关重要。编码的酶是癌症化疗药物的目标。这个基因的大部分转录本缺乏3'UTR(PMID: 3022294,3444407)。这些转录本的终止密码子是UAA,与在基因组和更长转录本中发现的UAG不同,因为polyA位点位于终止密码子内(PMID: 3444407,2157203)。一个相关的假基因已经在染色体10上被鉴定。[由RefSeq,2010年3月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
3
7
35718 bp
34.96
4
10

Tyms Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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