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中文小鼠
Twist1 - twist basic helix-loop-helix transcription factor 1
Alias:
Pde
pdt
Ska10
Twist
M-Twist
bHLHa38
Ska
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基本螺旋-环-螺旋(bHLH)转录因子与细胞谱系确定和分化有关。该基因编码一种从无脊椎动物到人类的进化保守的bHLH转录因子，最初在果蝇中被识别为涉及早期中胚层发育和胚胎背腹模式化的必需基因。该蛋白质通过调节上皮-间充质转化(EMT)过程在癌症中发挥作用，该过程对于转移启动和促进肿瘤进展至关重要。人类基因的突变与Saethre-Chotzen综合征(SCS)有关。该基因发生杂合突变的小鼠表现出与人类SCS患者相似的颅面结构和缺陷。[由RefSeq，2015年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Twist1 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
