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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Trp73 - transformation related protein 73
Alias:
p73
Tp73
TAp73
deltaNp73
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码肿瘤蛋白p73,它是p53家族成员,参与细胞对压力和发育的响应。这个家族成员包括p53、p63和p73,它们之间的序列相似性很高,使得p63和p73能够激活p53响应的基因,导致细胞周期停滞和凋亡。这个家族成员可以通过直接或间接的蛋白质相互作用以多种方式相互相互作用,从而调节相同的靶基因启动子或调节彼此的启动子。p73蛋白在正常组织中表达水平非常低,并且在许多肿瘤中差异表达。由于使用替代启动子、替代翻译起始位点和多种剪接变异,p73基因表达至少35种mRNA变异体。理论上,这可以解释29种不同的p73异构体;然而,大多数变异体的生物学有效性和全长性质尚未确定。[由RefSeq,2008年7月提供]
Related ID:
NCBI:22062
ENSEMBL:ENSMUSG00000029026
UNIPROT:Q9JJP2
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
22062
6
14
83627 bp
69.10
18
15
Trp73 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
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Protein
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* This data comes from NCBI.
Gene Expression
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