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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Traf6 - TNF receptor-associated factor 6
Alias:
2310003F17Rik
C630032O20Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码TNF受体相关因子(TRAF)家族的适配器蛋白质成员,该家族调节TNF受体和Toll/IL-1受体家族的成员的信号事件,以激活转录因子如NF-kappa-B和AP-1。这个基因的产物对于围产期和出生后存活是必不可少的。缺乏这个蛋白质的小鼠表现出骨病和表皮附器发育缺陷,正常B细胞分化,淋巴结器官发生,白介素-1信号传导,脂多糖信号传导和神经管闭合缺陷。这个蛋白质具有泛素连接酶活性。这个基因的可变剪接导致多个转录变异体。[RefSeq提供,2014年12月]
Related ID:
NCBI:22034
ENSEMBL:ENSMUSG00000027164
UNIPROT:P70196
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
22034
2
7
23249 bp
60.07
11
23
Traf6 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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