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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Tnf - tumor necrosis factor
Alias:
DIF
Tnfa
TNF-a
TNFSF2
Tnlg1f
Tnfsf1a
TNFalpha
TNF-alpha
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种属于肿瘤坏死因子(TNF)超家族的多种功能炎症细胞因子。这个家族的成员根据其初级序列、功能和结构进行分类。这种蛋白质作为II型跨膜蛋白合成,据报道被切割成具有不同生物学功能的产品。它在先天免疫反应和调节稳态中发挥着重要作用,但也与慢性炎症疾病有关。在缺乏这个基因的小鼠中,与对细菌感染反应的缺陷、形成有组织的毛囊树突状细胞网络和生发中心的缺陷以及缺乏主要B细胞滤泡有关。可变剪接导致多个转录变异体。[由RefSeq,2013年6月提供]
Related ID:
NCBI:21926
ENSEMBL:ENSMUSG00000024401
UNIPROT:P06804
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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21926
2
4
2641 bp
25.90
35
23
Tnf Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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