小鼠

Tnf - tumor necrosis factor

Alias:
DIF
Tnfa
TNF-a
TNFSF2
Tnlg1f
Tnfsf1a
TNFalpha
TNF-alpha
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种属于肿瘤坏死因子(TNF)超家族的多种功能炎症细胞因子。这个家族的成员根据其初级序列、功能和结构进行分类。这种蛋白质作为II型跨膜蛋白合成,据报道被切割成具有不同生物学功能的产品。它在先天免疫反应和调节稳态中发挥着重要作用,但也与慢性炎症疾病有关。在缺乏这个基因的小鼠中,与对细菌感染反应的缺陷、形成有组织的毛囊树突状细胞网络和生发中心的缺陷以及缺乏主要B细胞滤泡有关。可变剪接导致多个转录变异体。[由RefSeq,2013年6月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
2
4
2641 bp
25.90
35
23

Tnf Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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