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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Tgfb3 - transforming growth factor, beta 3
Alias:
Tgfb-3
TGF-beta-3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
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References Literature
这个基因编码一种分泌性的TGF-beta(转化生长因子-beta)超家族蛋白质的配体。这个家族的配体结合各种TGF-beta受体,导致SMAD家族转录因子的招募和激活,从而调控基因表达。编码的前原蛋白在蛋白水解过程中被加工成一种潜伏相关肽(LAP)和一种成熟的肽,并以潜伏形式存在,由成熟的肽同二聚体、LAP同二聚体和潜伏的TGF-beta结合蛋白组成,或者以活性形式存在,仅由成熟的肽同二聚体组成。成熟的肽也可以与其他TGF-beta家族成员形成异二聚体。这个蛋白参与胚胎发生和细胞分化,可能还在伤口愈合中发挥作用。这个基因的纯合性敲除小鼠表现出腭裂、肺发育延迟和新生儿死亡。[RefSeq提供,2016年8月]
Related ID:
NCBI:21809
ENSEMBL:ENSMUSG00000021253
UNIPROT:P17125
Basic Information
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21809
1
7
22299 bp
Unknown
9
8
Tgfb3 Genetics information (-)
GRCm39
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* This data comes from NCBI.
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